HLA-DRB3 Antibody - C-terminal region: HRP (ARP63521_P050-HRP)

• Gene Name:

  Major histocompatibility complex, class II, DR beta 3

• Gene Aliases:

  DRB3, HLA-DPB1, HLA-DR1B, HLA-DR3B, HLA-DRB3*

• Gene ID:

  3125

• Swiss Prot:

  P13762

• Accession Number:

  NP_072049

• Host:

  Rabbit

• Reactivity:

  Human, Pig

• Target:

  HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

• Partner Proteins:

  CDCA8; MAP3K13; YWHAE; PKM; HSP90AB1; HSP90AA1; HSPA8; MS4A1; ATP1B1; ANXA11; CTAG1B; POMC

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Human: 100%; Pig: 100%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  27kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  266

• NCBI Gene Symbol:

  HLA-DRB3

• Protein Name:

  HLA class II histocompatibility antigen, DR beta 4 chain

• Nucleotide Accession Number:

  NM_022555