HLA-DPB1 Antibody - middle region: FITC (ARP63264_P050-FITC)

• Gene Name:

  Major histocompatibility complex, class II, DP beta 1

• Gene Aliases:

  DPB1, HLA-DP, HLA-DPB, HLA-DP1B

• Gene ID:

  3115

• Swiss Prot:

  P04440

• Accession Number:

  NP_002112

• Host:

  Rabbit

• Reactivity:

  Human, Dog, Rabbit

• Target:

  HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

• Partner Proteins:

  LZTS2; TRIP6; LGR4; COPB1; RTN4; ROBO2; HLA-DPA1; CD74

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Dog: 86%; Human: 100%; Rabbit: 93%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  26kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  258

• NCBI Gene Symbol:

  HLA-DPB1

• Protein Name:

  HLA class II histocompatibility antigen, DP beta 1 chain

• Nucleotide Accession Number:

  NM_002121