BRCC3 Antibody - C-terminal region: Biotin (ARP61990_P050-Biotin)

• Gene Name:

  BRCA1/BRCA2-containing complex, subunit 3

• Gene Aliases:

  C6.1A, BRCC36, CXorf53

• Gene ID:

  79184

• Swiss Prot:

  P46736

• Accession Number:

  NP_077308

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig, Rabbit

• Target:

  This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy.

• Partner Proteins:

  FAM175B; UBC; FANCG; UIMC1; SUMO1; RABEP2; SMEK1; LARP7; CD2AP; WDHD1; SF3A1; GPHN; HNRNPR; TRIM28; HUWE1; MTA2; SPAG9; CCDC6; HDAC1; NR3C1; FAM175A; SUMO2; PAXIP1; MDC1; BRCA1; GRB2; BABAM1; BRE; BRCC3; COPS5; BACH1; BRCA2; BARD1; USP7; SHMT2; NDUFA10; M

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  IF, WB

• Purification:

  Affinity Purified

• Sample Type:

  BRCC3 is strongly supported by BioGPS gene expression data to be expressed in HeLa

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 86%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  35kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  316

• NCBI Gene Symbol:

  BRCC3

• Protein Name:

  Lys-63-specific deubiquitinase BRCC36

• Nucleotide Accession Number:

  NM_024332