GIT2 Antibody - C-terminal region : FITC (ARP61662_P050-FITC)

• Gene Name:

  G protein-coupled receptor kinase interacting ArfGAP 2

• Gene Aliases:

  PKL, CAT2, CAT-2

• Gene ID:

  9815

• Swiss Prot:

  Q14161

• Accession Number:

  NP_476510

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

• Target:

  This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined.

• Partner Proteins:

  UBC; QPRT; ATF5; CORO1A; HNRNPUL1; TNIP1; CALCOCO2; MVP; RUSC2; SAFB2; IKBKG; SPOP; TSN; TRAF1; TNFAIP3; RCVRN; PROX1; NME2; NFKBIB; SMAD3; LMNB1; KRT18; HGD; GUSB; GCH1; E2F2; C4BPA; ACTN1; ACTG1; Dlg4; POLR1B; USHBP1; RUFY1; SH3GLB2; KCTD5; UBQLN1; EDC4

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Pig: 100%; Rabbit: 93%; Rat: 79%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  83kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  759

• NCBI Gene Symbol:

  GIT2

• NCBI GB Accession Number:

  GIT2

• Host or Source:

  Rabbit

• Protein Name:

  ARF GTPase-activating protein GIT2

• Nucleotide Accession Number:

  NM_057169

• Peptide Sequence:

  VQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPE