PRKAR2A Antibody: HRP (ARP61562_P050-HRP)

• Gene Name:

  Protein kinase, cAMP-dependent, regulatory, type II, alpha

• Gene Aliases:

  PKR2, PRKAR2

• Gene ID:

  5576

• Swiss Prot:

  P13861

• Accession Number:

  NP_004148

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Dog, Horse, Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the following sequence GERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQ

• Target:

  CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER) .

• Partner Proteins:

  UBC; SUZ12; IMPDH2; GPS1; CSRP1; KPNA6; PRKACB; PRKACA; GCH1; WASF1; VCP; CIRBP; ELAVL1; PJA2; Dynll1; AKAP7; PPP1CB; MYCBPAP; ARFGEF2; AKAP2; RAB32; NBEA; AKAP12; AKAP11; AKAP10; AKAP8; AKAP6; AKAP3; AKAP5; AKAP13; AKAP9; CBFA2T3; SMAD3; AKAP1; CFTR; SMA

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Dog: 86%; Horse: 85%; Human: 100%; Mouse: 86%; Pig: 85%; Rabbit: 92%; Rat: 79%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  46 kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  404

• NCBI Gene Symbol:

  PRKAR2A

• Protein Name:

  CAMP-dependent protein kinase type II-alpha regulatory subunit

• Nucleotide Accession Number:

  NM_004157