KLRC1 Antibody - N-terminal region: Biotin (ARP61289_P050-Biotin)

• Gene Name:

  Killer cell lectin-like receptor subfamily C, member 1

• Gene Aliases:

  NKG2, NKG2A, CD159A

• Gene ID:

  3821

• Swiss Prot:

  P26715

• Accession Number:

  NP_002250

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Guinea Pig

• Target:

  Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.

• Partner Proteins:

  PMP22; MAL; KLRD1; PTPN6; PTPN11; HLA-E

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Guinea Pig: 79%; Human: 100%; Mouse: 86%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  26kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  233

• NCBI Gene Symbol:

  KLRC1

• Protein Name:

  NKG2-A/NKG2-B type II integral membrane protein

• Nucleotide Accession Number:

  NM_002259