HLA-DMA Antibody - N-terminal region: FITC (ARP61256_P050-FITC)

• Gene Name:

  Major histocompatibility complex, class II, DM alpha

• Gene Aliases:

  DMA, HLADM, RING6, D6S222E

• Gene ID:

  3108

• Swiss Prot:

  Q31604

• Accession Number:

  NP_006111

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Dog, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human HLA-DMA

• Target:

  HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.

• Partner Proteins:

  B3GAT1; U2AF2; RUNX1; UBC; CD82; HLA-DRB1; HLA-DOA; HLA-DRA; HLA-DMB; CD74

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Dog: 77%; Human: 100%; Rabbit: 82%; Rat: 86%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  29kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  261

• NCBI Gene Symbol:

  HLA-DMA

• Protein Name:

  DMA protein EMBL CAA60781.1

• Nucleotide Accession Number:

  NM_006120