SH2D1A Antibody - C-terminal region: Biotin (ARP60359_P050-Biotin)

• Gene Name:

  SH2 domain containing 1A

• Gene Aliases:

  LYP, SAP, XLP, DSHP, EBVS, IMD5, XLPD, MTCP1, XLPD1, SAP/SH2D1A

• Gene ID:

  4068

• Swiss Prot:

  O60880

• Accession Number:

  NP_002342

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Cow, Horse, Pig

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human SH2D1A

• Target:

  SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.

• Partner Proteins:

  LHX4; TNK2; UBC; LYN; MAPK11; MAPK1; ERBB3; EGFR; MAPK14; CD244; ELAVL1; SLAMF7; SLAMF6; ARHGEF7; CD84; SLAMF1; DOK1; FYB; LY9; ARHGEF6; LCK; FYN; GRB2

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Sample Type:

  SH2D1A is strongly supported by BioGPS gene expression data to be expressed in Jurkat

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 86%; Horse: 92%; Human: 100%; Pig: 100%; Rat: 93%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  14kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  128

• NCBI Gene Symbol:

  SH2D1A

• Protein Name:

  SH2 domain-containing protein 1A

• Nucleotide Accession Number:

  NM_002351