CALCOCO1 Antibody - N-terminal region: FITC (ARP57483_P050-FITC)

• Gene Name:

  Calcium binding and coiled-coil domain 1

• Gene Aliases:

  Cocoa, PP13275, calphoglin

• Gene ID:

  57658

• Swiss Prot:

  Q9P1Z2

• Accession Number:

  NP_065949

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human CALCOCO1

• Target:

  CALCOCO1 functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR) .CALCOCO1 is recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation CALCOCO1 acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. CALCOCO1 is involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. CALCOCO1 functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions.

• Partner Proteins:

  CWF19L2; CEP19; FAM161A; TBC1D15; DUSP13; ISOC1; GABARAPL2; NDC80; UBC; GRIK2; APP; APTX; EP300; CTNNB1; NEDD4; HIST1H4A; HIST1H3A; PCBD1; TBC1D17; CTNNBL1; CYTH3; SH3GL3; CRYBA2; CREBBP; MAPK1; KRT15; IPP; FOSL1

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  77kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  691

• NCBI Gene Symbol:

  CALCOCO1

• Protein Name:

  Calcium-binding and coiled-coil domain-containing protein 1

• Nucleotide Accession Number:

  NM_020898