CHMP1B Antibody - N-terminal region: HRP (ARP57408_P050-HRP)

• Gene Name:

  Charged multivesicular body protein 1B

• Gene Aliases:

  Vps46B, C10orf2, C18orf2, CHMP1.5, Vps46-2, C18-ORF2, hVps46-2

• Gene ID:

  57132

• Swiss Prot:

  Q7LBR1

• Accession Number:

  NP_065145

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Guinea Pig, Horse, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human CHMP1B

• Target:

  CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs) . Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]) .

• Partner Proteins:

  STAMBP; UBC; ATP6V1B1; CHMP4B; KNSTRN; CHMP1B; CHMP5; VPS4A; CNOT10; SNRNP200; SUCLG1; RAB11A; RASSF7; SSRP1; CHMP1A; USP54; USP8; SPAST; ELAVL1; IST1; VPS4B

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  22kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  199

• NCBI Gene Symbol:

  CHMP1B

• Protein Name:

  Charged multivesicular body protein 1b

• Nucleotide Accession Number:

  NM_020412