GSK1820795A

CAT: 0804-HY-111616-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-111616-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GSK1820795A, as a telmisartan analog, is a selective hGPR132a antagonist. GSK1820795A blocks activation of yeast cells expressing hGPR132a by N-acylamides[1]. GSK1820795A is also a angiotensin II antagonists and partial PPARγ agonists (compound 38) [2].

CAS Number

2650253-86-2

UNSPSC

12352005

Target

Angiotensin Receptor; PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Others; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gsk1820795a.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCN1C(CC2=CC=C(C3=C(C4=NNN=N4)C=CC=C3)C=C2)=C5C(C=CC(C6=NC(C=CC=C7)=C7N6CCCC)=C5)=N1

Molecular Formula

C35H34N8

Molecular Weight

566.70

References & Citations

[1]Foster JR, et al. N-Palmitoylglycine and other N-acylamides activate the lipid receptor G2A/GPR132. Pharmacol Res Perspect. 2019;7 (6) :e00542.|[2]Lamotte Y, Faucher N, Sançon J, et al. Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPARγ agonists. Bioorg Med Chem Lett. 2014;24 (4) :1098-1103.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AT1 Receptor; PPARγ

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