NSMCE2 Antibody - middle region: Biotin (ARP55690_P050-Biotin)

• Gene Name:

  Non-SMC element 2, MMS21 homolog (S. cerevisiae)

• Gene Aliases:

  NSE2, MMS21, ZMIZ7, C8orf36

• Gene ID:

  286053

• Swiss Prot:

  Q96MF7

• Accession Number:

  NP_775956

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Cow, Guinea Pig, Horse, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the middle region of human NSMCE2

• Target:

  NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

• Partner Proteins:

  TXLNA; PAN2; UBC; NSMCE1; SMC6; PDS5A; SMC5; WAPAL; PDS5B; STAG2; SMC3; SMC1A; SUMO1; TSNAX; RAD21; ETV1; SUMO2

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 86%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 79%; Rabbit: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  28kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  247

• NCBI Gene Symbol:

  NSMCE2

• Protein Name:

  E3 SUMO-protein ligase NSE2

• Nucleotide Accession Number:

  NM_173685