ORC6 Antibody - N-terminal region: FITC (ARP55021_P050-FITC)

• Gene Name:

  Origin recognition complex, subunit 6

• Gene Aliases:

  ORC6L

• Gene ID:

  23594

• Swiss Prot:

  Q9Y5N6

• Accession Number:

  NP_055136

• Host:

  Rabbit

• Reactivity:

  Human, Cow, Dog, Horse, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N-terminal region of Human ORC6

• Target:

  The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC6L is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.

• Partner Proteins:

  LHX4; SPAG5; UBC; ORC3; CDC7; ORC4; MCM7; MCM6; MCM4; MCM2; CDC6; APP; ORC2; SUMO2; XRCC5; XRCC6; HMGA1; MCM5; TERF2; ORC5; DBF4; CDC45; RPA1

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 92%; Dog: 100%; Horse: 77%; Human: 100%; Rabbit: 85%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  28kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  252

• NCBI Gene Symbol:

  ORC6

• Protein Name:

  Origin recognition complex subunit 6

• Nucleotide Accession Number:

  NM_014321