KPNA4 Antibody - N-terminal region: Biotin (ARP54676_P050-Biotin)

• Gene Name:

  Karyopherin alpha 4 (importin alpha 3)

• Gene Aliases:

  QIP1, SRP3, IPOA3

• Gene ID:

  3840

• Swiss Prot:

  O00629

• Accession Number:

  NP_002259

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human KPNA4

• Target:

  The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs) . Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. KPNA4 shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs) . Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

• Partner Proteins:

  HNRNPC; CYHR1; MAT2B; NUP50; PLAA; HSF1; UBC; LIN28A; rev; KPNA2; ACLY; SOX2; HDAC1; NACC1; CSNK2A1; AICDA; CBX5; APP; CUL3; DAXX; PARD3; ELAVL1; EXO1; CDKN1B; CUL4B; Ranbp2; Mki67; CTCF; MYC; TP53; H3F3A; RCC1; RAC1; RECQL; TGM2; KPNB1; CSE1L; ARRB2

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Sample Type:

  KPNA4 is supported by BioGPS gene expression data to be expressed in HeLa, MCF7

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  58kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  521

• NCBI Gene Symbol:

  KPNA4

• Protein Name:

  Importin subunit alpha-4

• Nucleotide Accession Number:

  NM_002268