DYNC1I2 Antibody - N-terminal region: HRP (ARP51954_P050-HRP)

• Gene Name:

  Dynein, cytoplasmic 1, intermediate chain 2

• Gene Aliases:

  IC2, DIC74, DNCI2, NEDMIBA

• Gene ID:

  1781

• Swiss Prot:

  Q13409

• Accession Number:

  NP_001369

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human DYNC1I2

• Target:

  DYNC1I2 acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.

• Partner Proteins:

  DYNLRB1; TUBGCP3; SUMO2; UBC; RNF2; EIF3CL; PRUNE2; DYNC1LI1; EIF3K; SERBP1; HNRNPA0; AKAP12; EIF3G; EIF3B; EIF3A; RPS26; RPS13; RPS5; PSMD8; PSMC5; YBX1; MAP2; DYNC1LI2; DYNC1H1; DDX1; ABCF1; vpr; PEX14; VCP; ECT2; CUL3; Dynll1; Dync1i2; SRRM2; DCTN1; PN

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  71kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  638

• NCBI Gene Symbol:

  DYNC1I2

• Protein Name:

  Cytoplasmic dynein 1 intermediate chain 2

• Nucleotide Accession Number:

  NM_001378