DYNLL1 Antibody - middle region: Biotin (ARP51261_P050-Biotin)

• Gene Name:

  Dynein, light chain, LC8-type 1

• Gene Aliases:

  LC8, PIN, DLC1, DLC8, LC8a, DNCL1, hdlc1, DNCLC1

• Gene ID:

  8655

• Swiss Prot:

  P63167

• Accession Number:

  NP_001032583

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the middle region of human DYNLL1

• Target:

  Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

• Partner Proteins:

  UBC; DYNC1I1; CCDC36; IQUB; AMBRA1; AMOTL2; KANK2; BECN1; BMI1; EED; GNB2L1; RPS21; RPS5; RPS3; RPS2; RPSA; HDLBP; FKBP3; FAU; DYNC1LI2; NRF1; AMOT; DYRK1B; DYRK1A; TERT; STK24; PRKACB; PRKACA; GSK3B; STK26; STK25; CSNK1A1; PAK1; UL122; IQCB1; BCL2L11; NA

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  10kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  89

• NCBI Gene Symbol:

  DYNLL1

• Protein Name:

  Dynein light chain 1, cytoplasmic

• Nucleotide Accession Number:

  NM_001037494