POLR3B Antibody - C-terminal region: HRP (ARP48821_P050-HRP)

• Gene Name:

  Polymerase (RNA) III (DNA directed) polypeptide B

• Gene Aliases:

  C128, HLD8, RPC2, INMAP

• Gene ID:

  55703

• Swiss Prot:

  Q9NW08

• Accession Number:

  NP_060552

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human POLR3B

• Target:

  POLR3B belongs to the RNA polymerase beta chain family. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3B is the second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

• Partner Proteins:

  SUMO2; UBC; POLR3H; TSR1; POLR1D; CRCP; POLR3A; POLR1C; POLR2H; POLR3D; RPAP2; RPAP1; GPN1; RAE1

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Goat: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 93%; Zebrafish: 100%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  128kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  1133

• NCBI Gene Symbol:

  POLR3B

• Protein Name:

  DNA-directed RNA polymerase III subunit RPC2

• Nucleotide Accession Number:

  NM_018082