SELENOS Antibody - middle region : Biotin (ARP48082_P050-Biotin)

• Gene Name:

  Selenoprotein S

• Gene Aliases:

  SELS, VIMP, ADO15, SBBI8, SEPS1, AD-015

• Gene ID:

  55829

• Swiss Prot:

  Q9BQE4

• Accession Number:

  NP_060915

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the middle region of human SELS

• Target:

  This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER) . It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) . Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019) .

• Partner Proteins:

  UBC; SRPK2; PTGS2; CAV1; DERL2; APOB; DERL1; VCP; KPNB1; AMFR; SYVN1; HERPUD1; SAA1; SVIP; NPLOC4; UFD1L; HSPA4

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 93%; Dog: 86%; Goat: 75%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 92%; Rat: 93%; Yeast: 90%; Zebrafish: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  21kDa

• References & Citations:

  Moses, E.K., Am. J. Obstet. Gynecol. 198 (3), 336 (2008)

• Shipping Conditions:

  Wet Ice

• Protein Length:

  189

• NCBI Gene Symbol:

  SELENOS

• NCBI GB Accession Number:

  SELENOS

• Host or Source:

  Rabbit

• Protein Name:

  Selenoprotein S

• Nucleotide Accession Number:

  NM_018445

• Peptide Sequence:

  PDVVVKRQEALAAARLKMQEELNAQVEKHKEKLKQLEEEKRRQKIEMWDS