RMI1 Antibody - N-terminal region: HRP (ARP46340_P050-HRP)

• Gene Name:

  RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)

• Gene Aliases:

  BLAP75, FAAP75, C9orf76

• Gene ID:

  80010

• Swiss Prot:

  Q9H9A7

• Accession Number:

  NP_079221

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human RMI1

• Target:

  RMI1 is an essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. RMI1 promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. RMI1 is required for BLM phosphorylation during mitosis. Within the BLM complex, RMI1 is required for BLM and TOP3A stability.RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]) .[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-136 BP327553.1 1-136 137-885 DN997105.1 9-757 886-2740 AL732446.4 14777-16631 2741-3508 BC039999.2 2566-3333

• Partner Proteins:

  APITD1; STRA13; UBC; RPA3; RPA2; RPA1; TOPBP1; BLM; NR1H2; UBE3A; HSPA13; PFDN1; Ercc6l; Top3a; FANCM; RMI2; FANCF; RMI1; FANCA

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 93%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  70kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  625

• NCBI Gene Symbol:

  RMI1

• Protein Name:

  RecQ-mediated genome instability protein 1

• Nucleotide Accession Number:

  NM_024945