RFC4 Antibody - middle region: FITC (ARP46087_P050-FITC)

• Gene Name:

  Replication factor C (activator 1) 4, 37kDa

• Gene Aliases:

  A1, RFC37

• Gene ID:

  5984

• Swiss Prot:

  P35249

• Accession Number:

  NP_002907

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the middle region of human RFC4

• Target:

  The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) . RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.

• Partner Proteins:

  RNF41; UBC; RFC5; PCNA; TP53; SUMO2; RPA3; RPA2; RPA1; RNF2; C14orf166; RTCB; RPL26L1; DIMT1; NELFB; EDC4; IGF2BP3; EIF2B2; EIF2B3; YBX3; QARS; NMT1; HNRNPM; MRE11A; ILF2; HNRNPU; FLII; FKBP3; EPRS; DHX9; DDX1; ABCF1; PARK2; TARDBP; MPG; RFC2; MYC; FN1; P

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Sample Type:

  RFC4 is supported by BioGPS gene expression data to be expressed in 721_B

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 93%; Dog: 86%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 93%; Rat: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  40kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  363

• NCBI Gene Symbol:

  RFC4

• Protein Name:

  Replication factor C subunit 4

• Nucleotide Accession Number:

  NM_002916