SPPL2B Antibody - N-terminal region: Biotin (ARP44988_P050-Biotin)

• Gene Name:

  Signal peptide peptidase like 2B

• Gene Aliases:

  IMP4, PSH4, PSL1, IMP-4

• Gene ID:

  56928

• Swiss Prot:

  Q8TCT7-3

• Accession Number:

  NP_694533

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Cow, Horse, Pig

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N-terminal region of Human SPPL2B

• Target:

  SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 79%; Horse: 86%; Human: 100%; Pig: 79%; Rat: 79%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  33kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  307

• NCBI Gene Symbol:

  SPPL2B

• Protein Name:

  Signal peptide peptidase-like 2B

• Nucleotide Accession Number:

  NM_152988