LDLR Antibody - C-terminal region: FITC (ARP44305_P050-FITC)

• Gene Name:

  Low density lipoprotein receptor

• Gene Aliases:

  FH, FHC, FHCL1, LDLCQ2

• Gene ID:

  3949

• Swiss Prot:

  P01130-2

• Accession Number:

  NP_001182732

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C-terminal region of Human LDLR

• Target:

  The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

• Partner Proteins:

  PCSK9; UBC; env; MAP4; PDIA3; CREBBP; PDIA4; HSP90B1; HSPA5; CANX; MYLIP; AP1M2; LDLR; SNX17; LDLRAP1; DAB1; PF4; APOE; APOB; LRPAP1; DAB2; CD36

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  75kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  682

• NCBI Gene Symbol:

  LDLR

• Protein Name:

  Low-density lipoprotein receptor

• Nucleotide Accession Number:

  NM_001195803