OPTN Antibody - C-terminal region: FITC (ARP43601_P050-FITC)

• Gene Name:

  Optineurin

• Gene Aliases:

  NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP

• Gene ID:

  10133

• Swiss Prot:

  Q96CV9

• Accession Number:

  NP_068815

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human OPTN

• Target:

  OPTN is the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

• Partner Proteins:

  RAB10; TNIP1; OPTN; DAZAP2; CDC23; UBC; PARK2; ZNF670; ZNF329; TBC1D15; ZNF398; CCDC53; MAP1LC3A; TBC1D17; HACE1; RAB25; RAB11B; SQSTM1; RAB11A; Rab8a; Tfrc; BRE; FAM178A; UQCRQ; GNAS; RAB12; EPS15; RAB14; MAP1LC3B; PIAS4; RNF11; RIPK1; TNFRSF1A; TNF; HTT

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 92%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  66kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  577

• NCBI Gene Symbol:

  OPTN

• Protein Name:

  Optineurin

• Nucleotide Accession Number:

  NM_021980