UBR1 Antibody - N-terminal region: HRP (ARP43459_P050-HRP)

• Gene Name:

  Ubiquitin protein ligase E3 component n-recognin 1

• Gene Aliases:

  JBS

• Gene ID:

  197131

• Swiss Prot:

  Q8IWV7

• Accession Number:

  NP_777576

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human UBR1

• Target:

  UBR1 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR1 may be involved in pancreatic homeostasis.The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

• Partner Proteins:

  CDC6; UBC; SHFM1; UBE2D1; CBX8; ZNF593; DNPH1; USP5; XPO1; PFAS; CSE1L; ATP6V1A; VCL; UCHL3; CUL2; RECQL4; TIRAP; DNAJB11; NUDT3; SPRY2; LAMTOR3; UBE2A; GSK3B; GADD45A; BCL2L1; UBE2Z; NSFL1C; UBXN1; UBXN7; FAF2; FAF1; FOS; HNRNPA1; NDUFA4L2; ARL15; BTBD2

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  200kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  1749

• NCBI Gene Symbol:

  UBR1

• Protein Name:

  E3 ubiquitin-protein ligase UBR1

• Nucleotide Accession Number:

  NM_174916