WWP1 Antibody - N-terminal region: HRP (ARP43084_P050-HRP)

• Gene Name:

  WW domain containing E3 ubiquitin protein ligase 1

• Gene Aliases:

  AIP5, Tiul1, hSDRP1

• Gene ID:

  11059

• Swiss Prot:

  Q9H0M0

• Accession Number:

  NP_008944

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human WWP1

• Target:

  WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. WWP1 is a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WWP1 belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes.WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

• Partner Proteins:

  SMAD3; FBXL18; WWP1; TRAF4; FAM189A2; UBE2L3; UBC; PTCH1; SMAD6; NOTCH1; EZH2; YWHAQ; CPSF6; TRAF6; LAPTM5; SMAD5; HSP90AA1; FBXL15; H2AFY2; PHF20L1; RNF11; ASH2L; PRKAA2; ATN1; LNX1; TP63; PTPN14; ERBB4; NFE2; SMAD7; SMAD4; SMAD2; SMAD1; RUNX2; Axin1; ga

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  IHC, WB

• Purification:

  Affinity Purified

• Sample Type:

  WWP1 is supported by BioGPS gene expression data to be expressed in HEK293T

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 100%; Rat: 100%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  105kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  922

• NCBI Gene Symbol:

  WWP1

• Protein Name:

  NEDD4-like E3 ubiquitin-protein ligase WWP1

• Nucleotide Accession Number:

  NM_007013