UBE2D2 Antibody - middle region: Biotin (ARP43010_P050-Biotin)

• Gene Name:

  Ubiquitin-conjugating enzyme E2D 2

• Gene Aliases:

  UBC4, PUBC1, UBCH4, UBC4/5, UBCH5B, E2 (17) KB2

• Gene ID:

  7322

• Swiss Prot:

  P62837

• Accession Number:

  NP_003330

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the middle region of human UBE2D2

• Target:

  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D2 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

• Partner Proteins:

  RNF26; CHFR; RBX1; DZIP3; UBA1; UBC; TRAF6; BIRC7; anapc11; ZNRF1; RNF146; MID1; MDM2; BIRC3; FZR1; ITCH; HRD1; CUL3; XIAP; MARCH7; RNF25; UBE2D2; RNF130; UBA6; CBLC; PARK2; TRIM21; KCMF1; RNF135; MUL1; MDM4; TRIM23; STUB1; CBL; UBTD1; RNF38; UBI4; RFFL

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  17kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  147

• NCBI Gene Symbol:

  UBE2D2

• Protein Name:

  Ubiquitin-conjugating enzyme E2 D2

• Nucleotide Accession Number:

  NM_003339