Olopatadine-d3 (hydrochloride)

Olopatadine-d3 (hydrochloride)

• CAS Number: 1331635-21-2
• UNSPSC Description: Olopatadine-d3 (hydrochloride) (ALO4943A-d3) is the deuterium labeled Olopatadine hydrochloride. Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis[1][2].
• Target Antigen: Histamine Receptor; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling;Others
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Inflammation/Immunology; Endocrinology
• Solubility: 10 mM in DMSO
• Smiles: C(CCN(C([2H])([2H])[2H])C)=C1C=2C(OCC=3C1=CC=CC3)=CC=C(CC(O)=O)C2.Cl
• Molecular Weight: 376.89
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Tamura, T., et al., Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52.|[3]Ohmori, K., et al., Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug. Jpn J Pharmacol, 2002. 88(4): p. 379-97.|[4]Yanni, J.M., et al., The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. J Ocul Pharmacol Ther, 1996. 12(4): p. 389-400.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported