DAB2 Antibody - N-terminal region: Biotin (ARP41937_P050-Biotin)

• Gene Name:

  Disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

• Gene Aliases:

  DOC2, DOC-2

• Gene ID:

  1601

• Swiss Prot:

  P98082-2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N-terminal region of Human DAB2

• Target:

  This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Partner Proteins:

  Fcho2; CPSF7; SMURF2; YLPM1; C14orf166; ACOT9; CPSF6; SF3B2; MALT1; HSPH1; SEC23B; SEC24B; NUP155; CDC16; TRIO; TFAP2A; AURKA; PYCR1; PRDX1; MYO6; HSPA1B; HNRNPL; GRB2; FN1; CLTC; AP2M1; CFTR; CCNT1; ACTB; AHCY; AP2B1; AP2A2; AP2A1; DYT10; ATXN1L; SH3KBP1

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  60kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  552

• NCBI Gene Symbol:

  DAB2

• Protein Name:

  Disabled homolog 2