FIP1L1 Antibody - C-terminal region: Biotin (ARP41031_P050-Biotin)

• Gene Name:

  FIP1 like 1 (S. cerevisiae)

• Gene Aliases:

  Rhe, FIP1, hFip1

• Gene ID:

  81608

• Swiss Prot:

  Q6UN15

• Accession Number:

  NP_112179

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human FIP1L1

• Target:

  FIP1L1 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly (A) polymerase and other factors to bring about cleavage and poly (A) addition. FIP1L1 contributes to poly (A) site recognition and stimulates poly (A) addition. It binds to U-rich RNA sequence elements surrounding the poly (A) site. FIP1L1 may act to tether poly (A) polymerase to the CPSF complex.

• Partner Proteins:

  ZMYND19; CPSF4; NAA10; SGTA; GOLGA2; STAU1; UBC; WWOX; SUZ12; RNF2; EZH2; PRMT6; PRMT2; CLK2; HDAC9; CSNK2A1; LIG4; WDR33; CPSF2; CPSF3; CPSF1; NUP153; APP; COPS5; HNRNPA1; SRRM2; RNPS1

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  IHC, WB

• Purification:

  Affinity Purified

• Sample Type:

  FIP1L1 is supported by BioGPS gene expression data to be expressed in Jurkat

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 86%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  65kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  594

• NCBI Gene Symbol:

  FIP1L1

• Protein Name:

  Pre-mRNA 3'-end-processing factor FIP1

• Nucleotide Accession Number:

  NM_030917