CHRNB2 Antibody - middle region: HRP (ARP37669_T100-HRP)

• Gene Name:

  Cholinergic receptor, nicotinic, beta 2 (neuronal)

• Gene Aliases:

  EFNL3, nAChRB2

• Gene ID:

  1141

• Swiss Prot:

  P17787

• Accession Number:

  NP_000739

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Yeast

• Immunogen:

  The immunogen is a synthetic peptide directed towards the middle region of human CHRNB2

• Target:

  Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.

• Partner Proteins:

  CRELD2; CHRNA4; CHRNA2

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 93%; Dog: 93%; Guinea Pig: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rat: 93%; Yeast: 77%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  57kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  502

• NCBI Gene Symbol:

  CHRNB2

• Protein Name:

  Neuronal acetylcholine receptor subunit beta-2

• Nucleotide Accession Number:

  NM_000748