DDX21 Antibody - C-terminal region : FITC (ARP36375_T100-FITC)

• Gene Name:

  DEAD (Asp-Glu-Ala-Asp) box helicase 21

• Gene Aliases:

  GUA, GURDB, RH-II/GU, RH-II/GuA

• Gene ID:

  9188

• Swiss Prot:

  Q9NR30

• Accession Number:

  NP_004719

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human DDX21

• Target:

  DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX21 encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.

• Partner Proteins:

  HUWE1; PA2G4; KPNA3; CEP250; SUMO2; SUMO3; STAU1; IVNS1ABP; UBC; MDM2; LGR4; SUMO1; ERG; WWOX; EED; rev; SRPK2; SRPK3; FBXO6; TARDBP; LYN; AICDA; PAN2; vif; WHSC1; VCAM1; ITGA4; IL7R; FN1; CSNK2A1; YWHAE; SMURF1; H2AFX; APTX; ESR1; FTSJ3; PCDHA2; RRP7A; R

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Sample Type:

  DDX21 is supported by BioGPS gene expression data to be expressed in HepG2

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 86%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Pig: 93%; Rabbit: 93%; Rat: 93%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  86kDa

• References & Citations:

  Henning, D., et al., (2003) J. Biol. Chem. 278 (52), 52307-52314

• Shipping Conditions:

  Wet Ice

• Protein Length:

  783

• NCBI Gene Symbol:

  DDX21

• NCBI GB Accession Number:

  DDX21

• Host or Source:

  Rabbit

• Protein Name:

  Nucleolar RNA helicase 2

• Nucleotide Accession Number:

  NM_004728

• Peptide Sequence:

  FRGQRDGNRRFRGQREGSRGPRGQRSGGGNKSNRSQNKGQKRSFSKAFGQ