NKRF Antibody - N-terminal region: HRP (ARP35929_P050-HRP)

• Gene Name:

  NFKB repressing factor

• Gene Aliases:

  NRF, ITBA4

• Gene ID:

  55922

• Swiss Prot:

  A3F768

• Accession Number:

  NP_060014

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human NKRF

• Target:

  This protein Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcriptionThis gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.

• Partner Proteins:

  STAU1; UBC; XRN2; BMI1; TARDBP; BARD1; CAND1; COPS5; CUL1; CUL3; SIRT7; HNRNPA1; SUMO2; VHL; DHX58; PRKRA; SUMO1; HMOX2; BCL6; REL; RELA; NFKB2; NFKB1

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 86%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 92%; Rat: 93%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  78kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  690

• NCBI Gene Symbol:

  NKRF

• Protein Name:

  NF-kappaB repressing factor EMBL ABN11234.1

• Nucleotide Accession Number:

  NM_017544