COPS2 Antibody - N-terminal region: HRP (ARP34189_T100-HRP)

• Gene Name:

  COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)

• Gene Aliases:

  CSN2, SGN2, ALIEN, TRIP15

• Gene ID:

  9318

• Swiss Prot:

  P61201

• Accession Number:

  NP_004227

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human COPS2

• Target:

  COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/Ion ChannelSBP. COPS2 is also innvolved in early stage of neuronal differentiation via its interaction with NIF3L1.

• Partner Proteins:

  UBC; GPS1; Map3k10; 5830415F09Rik; Taf1b; EP300; Crebbp; cul1; COPS7B; EPB41L1; COPS5; FBXW4; SENP8; vpr; IRF5; COPS4; COPS7A; COPS6; COPS8; COPS3; PMPCA; SEPHS1; EHBP1L1; SLAIN2; GAPVD1; PFKFB2; SEPT2; IRS2; GRK5; DDB2; LRR1; DCAF11; DDA1; RFWD2; DCAF8

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Goat: 91%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 86%; Zebrafish: 100%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  52kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  443

• NCBI Gene Symbol:

  COPS2

• Protein Name:

  COP9 signalosome complex subunit 2

• Nucleotide Accession Number:

  NM_004236