XRCC4 Antibody - middle region: FITC (ARP34125_P050-FITC)

• Gene Name:

  X-ray repair complementing defective repair in Chinese hamster cells 4

• Gene Aliases:

  SSMED

• Gene ID:

  7518

• Swiss Prot:

  Q13426

• Accession Number:

  NP_071801

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the middle region of human XRCC4

• Target:

  XRCC4 functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D) J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes.The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D) J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. This gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants.

• Partner Proteins:

  BIN1; FAM9B; ASTE1; XRCC4; LIG4; PNKP; PRKDC; CSNK2A1; VPS41; NUDT21; CWC27; DENR; USP7; SRP54; DDX5; APTX; ERG; SUMO2; UBC; CALM1; XRCC5; XRCC6; SETMAR; AHNAK; CAAP1; IFFO1; APLF; CHD3; NHEJ1; VIM; GZMB; ACTN1; NBN

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 92%; Yeast: 77%; Zebrafish: 85%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  38kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  336

• NCBI Gene Symbol:

  XRCC4

• Protein Name:

  DNA repair protein XRCC4

• Nucleotide Accession Number:

  NM_022406