UHRF1 Antibody - C-terminal region: Biotin (ARP32596_P050-Biotin)

• Gene Name:

  Ubiquitin-like with PHD and ring finger domains 1

• Gene Aliases:

  Np95, hNP95, ICBP90, RNF106, TDRD22, hUHRF1, huNp95

• Gene ID:

  29128

• Swiss Prot:

  Q96T88

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C-terminal region of Human UHRF1

• Target:

  This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

• Partner Proteins:

  UBC; H3F3B; H3F3A; HIST2H3D; HIST2H3A; HIST2H3C; UHRF1; HIST1H3F; HIST1H3B; HIST1H3E; HIST1H3C; HIST1H3D; HIST1H3A; HIST3H3; DNMT1; PARP1; PARP2; RNF2; USP7; KAT5; MPG; BTRC; CUL1; ZPR1; RB1; PRKACA; PML; SUV39H1; EZH2; SUZ12; UHRF2; USP11; HDAC1; ELAVL1

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Human: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  90kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  793

• NCBI Gene Symbol:

  UHRF1

• Protein Name:

  E3 ubiquitin-protein ligase UHRF1