GLI3 Antibody: Biotin (ARP32317_P050-Biotin)

• Gene Name:

  GLI family zinc finger 3

• Gene Aliases:

  PHS, ACLS, GCPS, PAPA, PAPB, PAP-A, PAPA1, PPDIV, GLI3FL, GLI3-190

• Gene ID:

  2737

• Swiss Prot:

  P10071

• Accession Number:

  NP_000159

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the following sequence KPDEDLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYETNCHWEGC

• Target:

  This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.

• Partner Proteins:

  ZIC3; SOX2; UBC; BTRC; PRKCA; GSK3A; CSNK1A1; SKI; HDAC1; MED12; CREBBP; STK36; SUFU; SMAD3; ZIC2; TWIST1; SMAD1; SMAD2; SMAD4; ZIC1; Sin3a; Shh; SAP18; Pias1

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  IHC

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  170 kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  1580

• NCBI Gene Symbol:

  GLI3

• Protein Name:

  Transcriptional activator GLI3

• Nucleotide Accession Number:

  NM_000168