Flunixin

• Description:

  Flunixin is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin shows anti-inflammatory effects[1][2].

• Product Name Alternative:

  Sch 14714

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  COX

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/flunixin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2C)O

• Molecular Formula:

  C14H11F3N2O2

• Molecular Weight:

  296.24

• Precautions:

  P264-P270-P405-P501

• References & Citations:

  [1]Z Cheng, et al. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998 Aug;22 (4) :353-66.|[2]Clare E Bryant, et al. Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res. 2003 Feb;64 (2) :211-5.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  COX-1; COX-2

• CAS Number:

  [38677-85-9]