Belotecan-d7 (hydrochloride)

Belotecan-d7 (hydrochloride)

• CAS Number: 1346598-22-8
• UNSPSC Description: Belotecan-d7 (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative[1][2].
• Target Antigen: Topoisomerase
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Cancer
• Smiles: O=C1N2C(C3=NC4=CC=CC=C4C(CCNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=C3C2)=CC5=C1COC([C@]5(O)CC)=O.Cl
• Molecular Weight: 477.00
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Kim YK, et al. Anticancer effects of CKD-602 (Camtobell?) via G2/M phase arrest in oral squamous cell carcinoma cell lines. Oncol Lett. 2015 Jan;9(1):136-142.|[3]Kim YY, et al. CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines. Oncol Rep. 2009 Jun;21(6):1413-9.|[4]Kim CY, et al. Antitumor activity of CKD-602, a camptothecin derivative, in a mouse glioma model. J Clin Neurosci. 2012 Feb;19(2):301-5.
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