Mizacorat

CAT: 0804-HY-120012-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-120012-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1].

CAS Number

1893415-00-3

Product Name Alternative

AZD9567

UNSPSC

12352005

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/mizacorat.html

Concentration

10mM

Purity

99.34

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

CC(F)(F)C(N[C@H]([C@H](OC1=CC2=C(N(C(C=C3)=CN(C)C3=O)N=C2)C=C1)C4=CC=CC=C4)C(C)C)=O

Molecular Formula

C27H28F2N4O3

Molecular Weight

494.53

References & Citations

[1]Ripa L, et al. Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J Med Chem. 2018 Mar 8;61 (5) :1785-1799.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Mizacorat

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