Survodutide

CAT: 0804-HY-P4146-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P4146-01Size:1 mg
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Description
Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake[1].
CAS Number
[2805997-46-8]
Product Name Alternative
BI 456906
UNSPSC
12352209
Target
GCGR; GLP Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/survodutide.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1(C(NC(CCC(N)=O)C(NCC(NC(C(O)C)C(NC(CC2=CC=CC=C2)C(NC(C(O)C)C(NC(CO)C(NC(CC(O)=O)C(NC(CC3=CC=C(C=C3)O)C(NC(CO)C(NC(CCCCN)C(NC(CC4=CC=C(C=C4)O)C(NC(CC(C)C)C(NC(CC(O)=O)C(NC(CCC(O)=O)C(NC(CCCNC(N)=N)C(NC(C)C(NC(C)C(NC(CCCCN)C(NC(CC(O)=O)C(NC(CC5=CC=CC=C5)C(NC(C(C)CC)C(NC(CCCCNC(CNC(CNC(C(NC(CNC(C(NC(CNC(CCC(C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)CO)=O)=O)CO)=O)=O)=O)C(NC(CC6=CNC7=CC=CC=C67)C(NC(CC(C)C)C(NC(CCC(O)=O)C(NC(CO)C(NC(C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)C(CC8=CNC=N8)N
Molecular Formula
C192H289N47O61
Molecular Weight
4231.63
References & Citations
[1]Tina Zimmermann, et al. BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy. Mol Metab. 2022 Dec:66:101633.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
Phase 3

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