Survodutide

• Description:

  Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake[1].

• Product Name Alternative:

  BI 456906

• UNSPSC:

  12352209

• Target:

  GCGR; GLP Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/survodutide.html

• Purity:

  99.92

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1(C(NC(CCC(N)=O)C(NCC(NC(C(O)C)C(NC(CC2=CC=CC=C2)C(NC(C(O)C)C(NC(CO)C(NC(CC(O)=O)C(NC(CC3=CC=C(C=C3)O)C(NC(CO)C(NC(CCCCN)C(NC(CC4=CC=C(C=C4)O)C(NC(CC(C)C)C(NC(CC(O)=O)C(NC(CCC(O)=O)C(NC(CCCNC(N)=N)C(NC(C)C(NC(C)C(NC(CCCCN)C(NC(CC(O)=O)C(NC(CC5=CC=CC=C5)C(NC(C(C)CC)C(NC(CCCCNC(CNC(CNC(C(NC(CNC(C(NC(CNC(CCC(C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)CO)=O)=O)CO)=O)=O)=O)C(NC(CC6=CNC7=CC=CC=C67)C(NC(CC(C)C)C(NC(CCC(O)=O)C(NC(CO)C(NC(C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)C(CC8=CNC=N8)N

• Molecular Formula:

  C192H289N47O61

• Molecular Weight:

  4231.63

• References & Citations:

  [1]Tina Zimmermann, et al. BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy. Mol Metab. 2022 Dec:66:101633.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  Phase 3

• CAS Number:

  [2805997-46-8]