Olodanrigan

• Description:

  Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons[1][2][3][4].

• Product Name Alternative:

  EMA401; PD-126055; (S) -EMA400

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Angiotensin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Endocrinology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/EMA401.html

• Purity:

  98.89

• Solubility:

  DMSO : 200 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles:

  O=C ([C@H]1N (C (C (C2=CC=CC=C2) C3=CC=CC=C3) =O) CC4=C (C (OCC5=CC=CC=C5) =C (OC) C=C4) C1) O

• Molecular Formula:

  C32H29NO5

• Molecular Weight:

  507.58

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Anand U et al. Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. Mol Pain. 2015 Jun 26;11:38.|[2]Suguru Koyama, et al. An Electroencephalography Bioassay for Preclinical Testing of Analgesic Efficacy.|[3]Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial. Lancet. 2014 May 10;383 (9929) :1637-47.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  AT2 Receptor

• CAS Number:

  1316755-16-4