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Olodanrigan

CAT: 0804-HY-13106-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13106-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons[1][2][3][4].
CAS Number
1316755-16-4
Product Name Alternative
EMA401; PD-126055; (S) -EMA400
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/EMA401.html
Purity
98.89
Solubility
DMSO : 200 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C([C@H]1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O
Molecular Formula
C32H29NO5
Molecular Weight
507.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Anand U et al. Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. Mol Pain. 2015 Jun 26;11:38.|[2]Suguru Koyama, et al. An Electroencephalography Bioassay for Preclinical Testing of Analgesic Efficacy.|[3]Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial. Lancet. 2014 May 10;383 (9929) :1637-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
AT2 Receptor

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T4431-01Olodanrigan
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A21691-100Olodanrigan 100mg
A21691-50Olodanrigan 50mg
A21691-10Olodanrigan 10mg
A21691-5Olodanrigan 5mg
A21691-200Olodanrigan 200mg
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