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Epoxomicin

CAT: 0804-HY-13821-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-13821-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity[1][2][3][4][5].
CAS Number
134381-21-8
Product Name Alternative
BU-4061T
UNSPSC
12352005
Target
Apoptosis; Proteasome
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Epoxomicin.html
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC([C@H]([C@@H](C)O)NC([C@@H](NC([C@H]([C@@H](C)CC)N(C)C(C)=O)=O)[C@@H](C)CC)=O)=O)CC(C)C)[C@@]1(C)CO1
Molecular Formula
C28H50N4O7
Molecular Weight
554.72
References & Citations
[1]Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9 (23) :3335-40.|[2]Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo) . 1992 Nov;45 (11) :1746-52.|[3]Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111 (11) :1771-82.|[4]McNaught KS, et al. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul;56 (1) :149-62.|[5]Meng L, et al. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A. 1999 Aug 31;96 (18) :10403-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
A2606-20Epoxomicin

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