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Nisoxetine

CAT: 0804-HY-B1704-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1704-01Size:5 mg
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Description
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3].
CAS Number
53179-07-0
UNSPSC
12352005
Target
Monoamine Transporter; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nisoxetine.html
Purity
98.56
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CNCCC(OC1=CC=CC=C1OC)C2=CC=CC=C2
Molecular Formula
C17H21NO2
Molecular Weight
271.35
References & Citations
[1]Béïque JC, et, al. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15; 349 (1) : 129-32. |[2]Cheetham SC, et, al. [3H]nisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan; 35 (1) : 63-70. |[3]Leung YM, et, al. Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. Pharmacol Rep. 2013; 65 (2) : 350-7. |[4]Bello NT, et al. High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor. J Obes. 2013;2013:457047.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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