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Losigamone

CAT: 0804-HY-106822-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106822-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Losigamone (AO-33) is an orally active antiepileptic compound. Losigamone blocks sodium channel. Losigamone stimulates the neuronal chloride channel and enhance chloride influx. Losigamone potentiates GABA-mediated responses and reduces epileptiform activity induced by chloride channel antagonists. Losigamone can be used for epilepsy research[1][2].
CAS Number
112856-44-7
Product Name Alternative
AO-33; (±) -Losigamone; LSG
UNSPSC
12352005
Target
Chloride Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/losigamone.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H](C1=C(C=CC=C1)Cl)[C@@]2([H])C(OC)=CC(O2)=O
Molecular Formula
C12H11ClO4
Molecular Weight
254.67
References & Citations
[1]Chen H, et al. Losigamone add-on therapy for focal epilepsy. Cochrane Database Syst Rev. 2019 Dec 11;12 (12) :CD009324.|[2]Jones FA, et al. The anticonvulsant effects of the enantiomers of losigamone. Br J Pharmacol. 1999 Nov;128 (6) :1223-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
T27845-01Losigamone

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