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Parsaclisib

CAT: 0804-HY-109068-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109068-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Parsaclisib (INCB050465) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib can be used for the research of relapsed or refractory B-cell malignancies[1][2][3].
CAS Number
1426698-88-5
Product Name Alternative
INCB050465; IBI-376
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Parsaclisib.html
Purity
99.75
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CCOC1=C([C@@H](C2)CNC2=O)C(F)=C(Cl)C=C1[C@@H](N3C4=NC=NC(N)=C4C(C)=N3)C
Molecular Formula
C20H22ClFN6O2
Molecular Weight
432.88
References & Citations
[1]Niu Shin, et al. Abstract 2671: INCB050465, a novel PI3Kδ inhibitor, synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. Cancer Research. 2015, Aug. 75 (15) .|[2]Shin N, et, al. Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy. J Pharmacol Exp Ther. 2020 Jul;374 (1) :211-222.|[3]Yue EW, et, al. INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ) . ACS Med Chem Lett. 2019 Oct 17;10 (11) :1554-1560.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PI3Kδ

Alternative Products

CatalogName
BA8737-5Parsaclisib
VED88948-01Parsaclisib hydrochloride
A13561-100Parsaclisib 100mg
A13561-50Parsaclisib 50mg
206961Parsaclisib HCl
A13561-10Parsaclisib 10mg
A13561-5Parsaclisib 5mg
A13561-25Parsaclisib 25mg
C01085-01Parsaclisib (INCB050465)
A13561-1Parsaclisib 1mg

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