Ethoxyquin

• Description :

  Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90) .

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H401

• Target :

  HSP; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Ethoxyquin.html

• Purity :

  98.76

• Solubility :

  DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  CC1=CC(C)(C)NC2=C1C=C(OCC)C=C2

• Molecular Formula :

  C14H19NO

• Molecular Weight :

  217.31

• Precautions :

  H302, H401

• References & Citations :

  [1]Sadikot T, et al. Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct;11 (8) :478-88.|[2]Zhu J, et al. Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation. Ann Neurol. 2013 Dec;74 (6) :893-904.|[3]Zhu J, et al. Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity. Sci Rep. 2016 Jun 28;6:28861.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSP90

• CAS Number :

  [91-53-2]