Bentracimab

CAT: 0804-HY-P99469-01Size: 1 mgDry Ice: YesHazardous: No
CAT#:0804-HY-P99469-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor (HY-1006) and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor[1].
CAS Number
[2260568-31-6]
Product Name Alternative
PB 2452; MEDI 2452
UNSPSC
12352203
Target
Others
Type
Inhibitory Antibodies
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bentracimab.html
Purity
99.9
Solubility
H2O
Smiles
[Bentracimab]
References & Citations
[1]Kathman SJ, et, al. Population pharmacokinetic-pharmacodynamic modeling of PB2452, a monoclonal antibody fragment being developed as a ticagrelor reversal agent, in healthy volunteers. CPT Pharmacometrics Syst Pharmacol. 2022 Jan;11 (1) :68-81.|[2]Almquist J, et, al. Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling. CPT Pharmacometrics Syst Pharmacol. 2016 Jun;5 (6) :313-23.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

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