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5-Methoxyflavone

CAT: 0804-HY-107790-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107790-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.
CAS Number
42079-78-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-Methoxyflavone.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=CC=CC(OC)=C13
Molecular Formula
C16H12O3
Molecular Weight
252.26
Precautions
H315, H319, H335
References & Citations
[1]Merlo S, et al. Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity. J Nat Prod. 2015 Nov 25;78 (11) :2704-11.|[2]Shanmugasundaram J, et al. Sedative-hypnotic like effect of 5-methoxyflavone in mice and investigation on possible mechanisms by in vivo and in silico methods. Biomed Pharmacother. 2018 Dec;108:85-94.|[3]Wudtiwai B, et al. Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines. J Hematol Oncol. 2011 Dec 21;4:52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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