Propiolactone

• Description :

  Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL) [1][2].

• Product Name Alternative :

  β-propiolactone; 2-Oxetanone; Betaprone

• UNSPSC :

  12352005

• Hazard Statement :

  H227, H315, H319, H330, H350

• Target :

  SARS-CoV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/propiolactone.html

• Purity :

  99.36

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1OCC1

• Molecular Formula :

  C3H4O2

• Molecular Weight :

  72.06

• Precautions :

  H227, H315, H319, H330, H350

• References & Citations :

  [1]Roberts A, et al. Immunogenicity and protective efficacy in mice and hamsters of a β-propiolactone inactivated whole virus SARS-CoV vaccine. Viral Immunol. 2010 Oct;23 (5) :509-19|[2]Kulkarni R, et al. Anti-SARS-CoV-2 IgG antibody response among Indian COVID-19 patients using β-propiolactone-inactivated, whole virus-based indirect ELISA. J Virol Methods. 2021 Jan;287:113996.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [57-57-8]