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Propiolactone

CAT: 0804-HY-107931-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107931-01Size:100 mg
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Description
Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL) [1][2].
CAS Number
[57-57-8]
Product Name Alternative
β-propiolactone; 2-Oxetanone; Betaprone
UNSPSC
12352005
Hazard Statement
H227, H315, H319, H330, H350
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/propiolactone.html
Purity
99.36
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1OCC1
Molecular Formula
C3H4O2
Molecular Weight
72.06
Precautions
H227, H315, H319, H330, H350
References & Citations
[1]Roberts A, et al. Immunogenicity and protective efficacy in mice and hamsters of a β-propiolactone inactivated whole virus SARS-CoV vaccine. Viral Immunol. 2010 Oct;23 (5) :509-19|[2]Kulkarni R, et al. Anti-SARS-CoV-2 IgG antibody response among Indian COVID-19 patients using β-propiolactone-inactivated, whole virus-based indirect ELISA. J Virol Methods. 2021 Jan;287:113996.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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