Tocainide HCl

Chemical Information
Tocainide Hydrochloride is the hydrochloride salt form of tocainide, a primary amine analog of lidocaine exhibiting class 1b antiarrhythmic property. Tocainide hydrochloride stabilizes the neuronal membrane by reversibly binding to and blocking open and inactivated voltage-gated sodium channels. This inhibits the inward sodium current required for the initiation and conduction of impulses and reduces the excitability of myocardial cells. This agent reduces the rate of rise and amplitude, and shortens the action-potential duration (APD) in both the Purkinje and muscle fibers. Tocainide also shortens the effective refractory period (ERP) of Purkinje fibers resulting in an increased the ERP/APD ratio. Overall these effects lead to the slowing of nerve impulses and stabilization of the heartbeat.
| CAS Number | 71395-14-7 |
| PubChem CID | 108173 |
| IUPAC Name | 2-amino-N-(2,6-dimethylphenyl)propanamide;hydrochloride |
| Molecular Formula | C11H17ClN2O |
| Molecular Weight | 228.72 |
| Topological Polar Surface Area | 55.1 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 2 |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 195 |
| Property | Value |
|---|---|
| Molecular Weight | 228.72 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 2 |
| Exact Mass | 228.1029409 |
| Monoisotopic Mass | 228.1029409 |
| Topological Polar Surface Area | 55.1 Ų |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 195 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
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